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KMID : 0624620080410120846
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BMB Reports
2008 Volume.41 No. 12 p.846 ~ p.851
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Identification of marbling-related candidate genes in M. longissimus dorsi of high- and low marbled Hanwoo (Korean Native Cattle) steers
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Lee Seung-Hwan
Cho Yong-Min
Lee Sang-Hong
Kim Bum-Soo
Kim Nam-Kuk
Choy Yeon-Ho
Kim Kyoung-Hoon
Yoon Du-Hak
Im Seok-Ki
Oh Sung-Jong
Park Eung-Woo
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Abstract
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This study was conducted to identify marbling-related candidate genes in M. longissimus dorsi of high- and low-marbled Hanwoo. The longissimus dorsi muscles were selected for gene expression from eight Hanwoo steer carcasses based on crude fat content. In the analysis of variance, gene expression of five candidate genes, FABP4, SCD, PPARγ, Titin and Nebulin was determined to be significantly different between high- and low-marbled Hanwoo steers (P ＜ 0.0001). The Pik-4 and CaMK II genes were also shown to have a significant effect on crude fat content (P ＜ 0.01). In the analysis of the differential expression between high- and low marbled groups, FABP4 gene expression was approximately 2 times higher in the high marbled group relative to the low marbled group. However, the PPARγ and SCD gene were highly expressed in the low marbled group. In addition, Titin and Nebulin were highly expressed in the low marbled group when placed under relatively high shear force. Finally, the Pik-4 and CaM K II gene also displayed a high expression pattern in the low marbled group.
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KEYWORD
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Analysis of Variance (ANOVA), Hanwoo (Korean Native Cattle), Marbling (intramuscular fat)-related candidate gene
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